The Association between Social Network Betweenness and Coronary Calcium: A Baseline Study of Patients with a High Risk of Cardiovascular Disease

AIM The association of social networks with cardiovascular disease (CVD) has been demonstrated through various studies. This study aimed to examine the association between social network betweenness -a network position of mediating between diverse social groups-and coronary artery calcium. METHODS The data of 1,384 participants from the Cardiovascular and Metabolic Disease Etiology Research Center-High Risk Cohort, a prospective cohort study enrolling patients with a high risk of developing CVD (clinicaltrials.gov: NCT02003781), were analyzed. The deficiency in social network betweenness was measured in two ways: only-family networks, in which a respondent had networks with only family members, and no-cutpoint networks, in which the respondent does not function as a point of bridging between two or more social groups that are not directly connected. RESULTS Participants who had higher coronary artery calcium scores (CACSs) were likely to have a smaller network size (p＜0.001), only-family networks (p＜0.001), and no-cutpoint networks (p＜0.001). Multiple logistic regression analyses revealed no significant association between network size and CACS. Only no-cutpoint networks had a significant relationship with CACS ＞400 (odds ratio, 1.72; 95% confidence interval, 1.07-2.77; p=0.026). The association was stronger among older (age ＞60 years) and female respondents. CONCLUSION Deficiency in social network betweenness is closely related to coronary calcium in participants with a high risk of CVD. To generalize these results to a general population, further study should be performed.